Sanctions have long ceased to be an exceptional tool of world politics — today they have become an everyday challenge for economies, especially for regions whose well-being depends on global supply chains or foreign investments. After 2022, this issue has become even more acute: for example, Russian regions focused on raw material exports faced a sharp reduction in markets, while European industrial zones faced a shortage of energy resources. But why do some territories adapt faster, while others sink into crisis? The answer to this question is not just interesting — it is critically important for developing strategies that will help maintain stability in conditions of uncertainty. The goal of this work is not just to list resilience factors, but to understand how they interact in real conditions. We will not limit ourselves to general phrases like "economic diversification" — instead, we will try to understand the specific mechanisms that allow regions to mitigate the impact of sanctions. For example, why does Tatarstan, despite its dependence on oil refining, show a smaller decline than some single-industry towns in Siberia? Or how did the Kaliningrad region, finding itself in a logistical blockade, find alternative trade routes? The research tasks follow from these questions: To identify indicators that truly reflect resilience, rather than simply duplicating standard economic metrics. To understand how different types of sanctions (from technology bans to asset freezes) hit specific sectors of the regional economy. To assess the extent to which support measures from authorities (federal or local) compensate for these blows. The novelty of the work lies in the attempt to combine "soft" data (for example, interviews with small business representatives) with hard statistics. Most studies focus either on the macro level or on individual cases, but we will try to show the relationship between state policy, company decisions, and population behavior. [1] The object of the research is the regions of Russia that were subjected to sanctions after 2022, but for contrast, we will add examples from EU countries (e.g., Germany or Poland) to see if there are universal principles of resilience. The subject of the research is not just economic indicators, but their dynamics under external pressure, including non-obvious factors like labor migration or changes in consumer habits. [2]